Ultrasonic Probe Sonicator & Homogenizer

LeelaSonic probe sonicators are priced from approximately ₹35,000 for the 120W model to ₹2,50,000 for the 1500W industrial model. Price depends on power output, probe diameter and accessories. Factory-direct from Dombivli — no dealer margin. Get a price quote today.

A probe sonicator delivers high-intensity focused energy directly into the sample via a titanium tip — ideal for cell disruption, nanoparticle dispersion and emulsification. A sonicator bath delivers gentle indirect sonication — better for HPLC degassing, glassware cleaning and dissolution. For biological samples, a probe sonicator with pulse mode and ice cooling is the standard method.

In pharmaceutical R&D and biotech, ultrasonic probe sonicators are used for cell disruption (lysis), protein and enzyme extraction, nanoparticle formulation and liposome preparation, DNA/RNA shearing for genomics, emulsification for drug delivery systems, and dispersion of API particles in suspension formulations. It is standard equipment in most IITs, CSIR labs, pharma R&D centres and biotech companies across India.

The terms probe sonicator, ultrasonicator, ultrasonic homogenizer and ultrasonic cell disruptor all refer to the same type of equipment — a high-frequency ultrasonic processor with a titanium probe tip. The difference is terminology: research labs often say "probe sonicator" or "sonicator," while material scientists say "ultrasonicator" and food/pharma industries say "homogenizer" or "liquid processor."

Probe diameter determines the volume range. A 6mm micro probe is used for 0.5ml–50ml (microtubes). A 13mm probe handles 10ml–200ml (standard lab use). A 20–25mm probe is used for 50ml–1000ml (scale-up). A 34mm probe handles 500ml–5L (industrial). Share your sample volume and application and we will confirm the correct probe.

Pulse mode alternates between sonication ON and OFF (e.g. 2 sec ON, 2 sec OFF). This prevents sample overheating — critical for heat-sensitive biological samples like proteins, enzymes and nucleic acids. Always use pulse mode with ice cooling for biological applications. For nanoparticle dispersion and emulsification, continuous mode is generally acceptable.

Strongly recommended. Probe sonicators operating at 20–28 kHz generate noise of 90–100 dB in the audible range, which causes hearing fatigue during extended use. LeelaSonic supplies optional soundproof enclosures for all models that reduce noise to safe levels and also serve as secondary containment during processing.

Can it process nanoparticles?

Yes. The high-amplitude ultrasonic waves create intense cavitation shear forces capable of deagglomerating and dispersing nanoparticles — including CNTs, graphene, ZnO, TiO₂ and metal oxides — uniformly in liquid suspension. Ultrasonic dispersion produces narrower particle size distributions than mechanical stirring and is the standard method for preparing nanoparticle suspensions for research and formulation.